When amphetamine was first synthesized in 1887, by the German chemist L. Edeleano, the stimulant effects were not noticed. In the early 1930s, when amphetamine's CNS stimulant properties and use as a respiratory stimulant were discovered it was marketed as an inhaler for nasal congestion (Benzedrine©). Benzedrine is the trade name for the drug amphetamine; dextroamphetamine is marketed as Dexedrine. Methamphetamine, a potent stimulant marketed as Desoxyn, is the most rapidly acting amphetamine. Now such inhalants have been banned because of their toxicity but are still available by prescription for limited uses.

Amphetamines may produce acute systemic effects, which includes cardiac irregularities and gastric disturbances. Chronic use frequently results in insomnia, hyperactivity, irritability, and aggressive behavior.

Abuse of amphetamine began rising during the 1960s and 1970s with the discovery that the intravenous injection of amphetamines (particularly methamphetamine) produced enhanced euphoric effects with a more rapid onset than oral administration. Amphetamine is also popular with athletes in training because of the enhanced performance consequent on increased cardiac output.

Popularly known as bennies, crank, speed, pep pills, wakeups, or uppers, amphetamines are easily addictive and abused. Users run the risk of becoming psychologically dependent on the drugs and, developing a tolerance for them. This results in the requirement of increasingly larger doses for the same effect.

Addiction could end in psychosis or death from hyper-exhaustion or cardiac arrest. Amphetamine-induced psychosis shows remarkable similarity to schizophrenia, with paranoia and hallucinations.

There are no known over-the-counter drugs that contain amphetamines though a number of such drugs test false positive for amphetamine.

Most drugs work through the interactions of the receptors found on the cell's surface or the enzymes contained in the cells. The enzymes are responsible for regulating the pace of how chemical reacts. The molecules of enzyme and receptor have a particular three-dimensioned structure that permits only specific substances to attach to it. These substances should precisely fit to these molecules.

There are a lot of factors to consider when understanding how drugs work or how the enzyme and receptors molecules react to the chemicals from these drugs.

Each kind of drug has a diverse effect on the different types of body cells. The drug works only if the substance put forth an effort to influence and make changes on some of the body's processes and cells. If there is no reaction, the drug did not work.

Before the drug intake, three factors that could affect the body's response to the drug are the following:

1. Dose - Majority of drugs have no effect to one's body if the minimum level of dosage is not given. Hereditary factors may play a role on the level of dosage to be given to an individual. Median lethal dose is the drug's dose where 50 percent of the tested persons have shown positive response on the drug's effectiveness.

2. Amount of time - There are drugs that are effective immediately once it entered the body's circulatory system. Some of the drugs may take effect after a few hours and sometimes days. Drugs that have an immediate effect are defined as short term and are given in single doses while the drugs for long term are often provided in repetitive dosages.

3. Route of how it is administered - This is a very important factor in determining how the drug will influence the body. The methods on how the drug is administered are oral, inhalation, injection, vaginally or rectally.

Other significant factors are the individual's metabolism rate, psychological environment, excretion route, hereditary influences, weight, sex and age. A drug's effect on one's body also depends on the drug's ability to interact with the body cells and the function of these body cells.

A lot of cases require that the drug and cell membrane must have a union so that the drug's effect will take place. The receptor site of the cell is where the interaction always takes place. This is often referred to as a "lock-and-key" relationship between the drug and receptor site. These are the ways on how some of the drugs act on the body cells from the receptor site's point:

1. The cell's activity is either increased, decrease or blocked.

2. The missing component required by a cell to function what is moon rock drug properly is replaced.

3. The drug helps in moving the substance throughout the cell membrane.

There are also cases after entering the body the drug should be altered chemically before it can cause any effect on the cells. The chemical changes may happen on the cell's receptor site or the individual's intestines or stomach.